Publications by authors named "N R Mesa-Herrera"
Membrane attack complex (C5b-9 complex or Mac), is strongly present in lesional skin from patients with endemic pemphigus foliaceus in El Bagre, Colombia.
Ana Maria Abreu-Velez Yulieth A Upegui-Zapata Carlos A Valencia-Yepes Eduardo Upegui-Quiceno Natalia-Regina Mesa-Herrera
J Cutan Pathol
December 2019
Article Synopsis
- El Bagre endemic pemphigus foliaceus (El Bagre-EPF) is a newly identified variant of a skin disease in Colombia, and the study focuses on the role of complement/C5b-9 in the affected skin of patients compared to healthy controls.
- The research involved a case-control study with 43 patients and 43 matched controls, using skin biopsies to analyze the presence of complement and antibody levels.
- Results showed that complement/C5b-9 was present in all patients with El Bagre-EPF but absent in controls, and higher autoantibody titers were linked to more severe skin lesions.
Article Synopsis
- A new variant of endemic pemphigus foliaceus called El Bagre-EPF was identified in El Bagre, Colombia, with patients showing autoimmunity to arrector pili muscles (APM).
- In a study involving 30 patients and 30 healthy controls, researchers used various testing methods to analyze skin biopsies and discovered that 27 out of 30 patients had autoantibodies to APM.
- The findings suggest a significant immune response against certain cell junction proteins in El Bagre-EPF patients, indicating a complex polyclonal response involving various immune components.