Publications by authors named "N R McLean"
Müller-Weiss disease (MWD) is a poorly understood orthopedic condition first described in 1927 that causes chronic pain across the midfoot and hindfoot. The etiology is uncertain but includes navicular dysplasia, osteochondritis, and trauma. The initial management is conservative, aiming to reduce the patient's symptoms, and includes analgesia, footwear, and activity modification.
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- The study focuses on optimizing inhibitors for epidermal growth factor receptor (EGFR) Exon20 insertions (Ex20Ins) using structure-based drug design (SBDD).
- A new compound was discovered that is both effective against EGFR Ex20Ins and able to cross the blood-brain barrier in preclinical tests.
- The design process involved creating a novel bicyclic structure, making strategic modifications to improve stability and enhance brain exposure by refining key molecular properties.
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- The study aimed to investigate the prevalence of squeezable food pouches among infants and young children, and their potential effects on energy intake and body mass index (BMI).
- Researchers surveyed 933 children in New Zealand, and found that while pouch usage decreased as children grew older, the effect on their energy intake varied by age.
- Notably, preschool children who frequently used pouches consumed less energy compared to non-users, while no significant differences in BMI were observed related to pouch use, suggesting concerns about pouches may be overstated.
Optimal nutrition during infancy is critical given its influence on lifelong health and wellbeing. Two novel methods of infant complementary feeding, commercial baby food pouch use and baby-led weaning (BLW), are becoming increasingly popular worldwide. Household food insecurity may influence complementary feeding practices adopted by families, but no studies have investigated the use of BLW and baby food pouches in families experiencing food insecurity.
View Article and Find Full Text PDFIn recent years, we and others have identified a number of enhancers that, when incorporated into rAAV vectors, can restrict the transgene expression to particular neuronal populations. Yet, viral tools to access and manipulate fine neuronal subtypes are still limited. Here, we performed systematic analysis of single cell genomic data to identify enhancer candidates for each of the cortical interneuron subtypes.
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