Publications by authors named "N R Makhmudova"
Inflammatory diseases of the pharynx occupy one of the leading places in the structure of otorhinolaryngological pathology. Acute and chronic inflammatory processes in the pharynx, as well as exacerbations of the latter, are faced by doctors of a wide range of specialties. Oropharyngeal swab laboratory testing is required to identify a specific pathogen, which takes time.
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- Influenza viruses can interact with Staphylococcus aureus, increasing the risk of severe bacterial pneumonia, a leading cause of death during influenza outbreaks, especially since there is no vaccine for S. aureus and antibiotic resistance is growing.
- The study tested a vaccine using virus-like particles (VLP) that expressed an influenza protein in mice, finding that a single low dose could help prevent severe bacterial infections after influenza.
- However, while the vaccine generated a strong immune response against the influenza virus, it wasn't enough to stop the replication of different strains of the virus or protect against subsequent bacterial infections, indicating that more comprehensive strategies may be needed.
Antiviral drugs can play a significant role in the control of influenza. Umifenovir (Arbidol) is licensed and widely used in Russia for the prophylaxis and/or treatment of influenza. We evaluated the susceptibility to umifenovir of reference influenza A and B viruses and influenza A viruses isolated from patients in the ARBITR clinical trial in 2012-2014 seasons.
View Article and Find Full Text PDF[EFFECTIVENESS OF FULLERENE-(TRIS-AMINOCAPRONIC ACID) HYDRATE IN THE MODEL OF EXPERIMENTAL VIRAL-BACTERIAL PNEUMONIA OF MICE].
Zh Mikrobiol Epidemiol Immunobiol
February 2016
Aim: Study the effectiveness of the substance and various drug formulations of fullerene-(tris-aminocapronic acid) hydrate (FTAAH onwards) in the model of experimental viral-bacterial pneumonia of mice.
Materials And Methods: BALB/c mice were infected with influenza virus A/California/04/2009 and subsequently infected with Staphylococcus aureus. The animals were treated after viral infection with the substance and various drug forms of FTAAH, as well as comparative preparations--oseltamivir and arbidol.
Pneumonia often occurs as a secondary infection after influenza and accounts for a large proportion of the morbidity and mortality associated with seasonal and pandemic influenza outbreaks. The efficacy of umifenovir (Arbidol) was investigated on a murine model of S. aureus pneumonia following A/California/04/2009 (H1N1) influenza virusinfection.
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