Publications by authors named "N R Landau"
Background: While immunotherapy has been highly successful for the treatment of some cancers, for others, the immune response to tumor antigens is weak leading to treatment failure. The resistance of tumors to checkpoint inhibitor therapy may be caused by T cell exhaustion resulting from checkpoint activation.
Methods: In this study, lentiviral vectors that expressed T cell epitopes of an experimentally introduced tumor antigen, ovalbumin, or the endogenous tumor antigen, Trp1 were developed.
Article Synopsis
- * A new lentiviral transduction protocol was developed to successfully manipulate long-term repopulating quiescent HSC by addressing barriers like vector entry and limited resource availability.
- * This enhanced method, using cyclosporin H and deoxynucleosides, results in effective level of genetic modifications and improved HSC engraftment compared to traditional culture techniques, paving the way for future genetic engineering strategies.
Article Synopsis
- The study investigates the link between low ALT (Alanine-aminotransferase) levels and increased mortality risk in hospitalized COVID-19 patients, given its association with sarcopenia and frailty.
- Data from 357 patients showed that those with low ALT were more likely to die, with a hazard ratio of 1.82, indicating that low ALT is a significant predictor of worse outcomes.
- The research concludes that low ALT levels are independently associated with a higher risk of mortality in COVID-19 patients, even after accounting for other risk factors like age and comorbidities.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subject to restriction by several interferon-inducible host proteins. To identify novel factors that limit replication of the virus, we tested a panel of genes that we found were induced by interferon treatment of primary human monocytes by RNA sequencing. Further analysis showed that one of the several candidates genes tested, receptor transporter protein 4 (RTP4), that had previously been shown to restrict flavivirus replication, prevented the replication of the human coronavirus HCoV-OC43.
View Article and Find Full Text PDF