Publications by authors named "N R Ignatenko"
The treatment of canine transmissible venereal tumour (CTVT) has evolved since its initial description in 1810. Initially considered untreatable in the early 20th century, extensive research over time has significantly advanced our understanding of its aetiopathogenesis. This led to successful chemotherapy treatments, which have shown superior outcomes compared to surgical interventions.
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- - The study aimed to evaluate how the serine protease KLK6 affects colorectal cancer development in mice with a mutant tumor suppressor gene, finding that KLK6 expression increases significantly in tumors compared to normal tissue.
- - Techniques like immunohistochemistry confirmed KLK6 presence, and genetically altered mice lacking KLK6 showed smaller tumor sizes and fewer adenomas, indicating KLK6's crucial role in tumor growth.
- - The research highlights KLK6 as an important factor for intestinal tumorigenesis, suggesting it could be useful for early diagnosis of colorectal cancer.
Soft tissue tumors/sarcomas (STSs) in felines, encompassing a variety of mesenchymal tumors with similar histomorphological features, present diagnostic challenges due to their diverse cellular origins and the overlap with other tumor types such as feline sarcoid. This study aimed to delineate the clinical, histomorphological, and immunohistochemical characteristics of 34 feline facial spindle cell tumors affecting 29 cats, including testing for bovine papillomavirus type 14 (BPV14), the virus causing feline sarcoids. Only five out of 12 tumors previously diagnosed as feline sarcoids based on histomorphology were confirmed by PCR for BPV14, underscoring the importance of comprehensive diagnostic approaches to accurately distinguish between STSs and feline sarcoids.
View Article and Find Full Text PDFThe treatment of tuberculosis is still a challenging process due to the widespread of pathogen strains resistant to antibacterial drugs, as well as the undesirable effects of anti-tuberculosis therapy. Hence, the development of safe and effective new anti-antitubercular agents, in addition to suitable nanocarrier systems, has become of utmost importance and necessity. Our research aims to develop liposomal vesicles that contain newly synthesized compounds with antimycobacterial action.
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