Detecting play behaviour in weaned dairy calves using accelerometer data.

This research paper describes a validation study evaluating the ability of IceTag accelerometers (Peacock Technology, UK) to detect play behaviour in weaned dairy calves. Play behaviour is commonly observed in young animals and is regarded as an indicator of positive welfare states. Eight Holstein Friesian calves aged three to five months old were monitored using leg-mounted accelerometers for 48 h.

Mixed practice was my plan…then cattle health specialisation caught my attention.

Gaining experience in mixed practice was the starting point for Nicola Gladden, then locuming and travel gave her the space to decide which career route to follow next, choosing a residency pathway.

Pharmacokinetics of bromoform in dairy heifers.

Aims: To determine the pharmacokinetics in dairy heifers after oral and IV administration of bromoform, a potential antimethanogenic agent found in red seaweed, spp.

Methods: Twenty-four dairy heifers with a mean weight of 319 (SD 36.9) kg were used.

Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller.

The Chaperonin Containing Tailless polypeptide 1 (CCT) complex is an essential protein folding machine with a diverse clientele of substrates, including many proteins with β-propeller domains. Here, we determine the structures of human CCT in complex with its accessory co-chaperone, phosducin-like protein 1 (PhLP1), in the process of folding Gβ, a component of Regulator of G protein Signaling (RGS) complexes. Cryoelectron microscopy (cryo-EM) and image processing reveal an ensemble of distinct snapshots that represent the folding trajectory of Gβ from an unfolded molten globule to a fully folded β-propeller.

Sepsis Program Activities in Acute Care Hospitals - National Healthcare Safety Network, United States, 2022.

Sepsis, life-threatening organ dysfunction secondary to infection, contributes to at least 1.7 million adult hospitalizations and at least 350,000 deaths annually in the United States. Sepsis care is complex, requiring the coordination of multiple hospital departments and disciplines.