Publications by authors named "N R Every"
Article Synopsis
- The study aimed to evaluate how the duration of chest pain affects the sensitivity and specificity of early cardiac marker tests (CK-MB and myoglobin) in emergency department patients with nondiagnostic ECGs.
- It involved 5005 patients over 25 years old, stratified by pain duration, and found that sensitivity of the markers increased with longer chest pain duration, but never exceeded 73% for CK-MB and 73% for myoglobin.
- The results indicate that using single assays at early time points is insufficient to rule out acute myocardial infarction (AMI), highlighting the need for serial testing and longer observation periods to accurately assess AMI risk.
Background: There is a concern that patients with acute coronary syndrome (ACS) admitted to primary care hospitals (without on-site cardiac procedures) may be at risk for worse outcomes compared with patients admitted to tertiary care hospitals. In addition to mortality, one way to assess patient outcomes is via health status and rehospitalization rates. We compared the health status and rehospitalization of patients with ACS admitted to primary versus tertiary care Veterans Affairs hospitals.
View Article and Find Full Text PDFWe determined the effects of early statin treatment in acute myocardial infarction (AMI) on in-hospital morbidity and mortality. Experimental models of ischemia and reperfusion have shown that statins have early cardioprotective effects. However, the effect of statin use within the first 24 hours of admission on early morbidity and mortality in AMI has not been well studied.
View Article and Find Full Text PDFBackground: Cardiac biomarkers are routinely obtained in the setting of suspected myocardial ischemia and infarction. Evidence suggests these markers may correlate with functional and clinical outcomes, but the strength of this correlation is unclear. The relationship between enzyme measures of myocardial necrosis and left ventricular performance and adverse clinical outcomes were explored.
View Article and Find Full Text PDFContext: Early mechanical revascularization in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock is a therapeutic strategy that reduces mortality. It has been a class I recommendation in guidelines from the American College of Cardiology and the American Heart Association since 1999 for patients younger than 75 years. However, little is known about implementation of these guidelines in practice.
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