Publications by authors named "N Punt"
Article Synopsis
- The aim was to determine whether continuous or multiple daily doses of PTH would be more effective in reducing urinary calcium excretion and lowering the nephrolithiasis risk, using a pharmacokinetic-pharmacodynamic (PKPD) model.
- The results indicated that continuous PTH infusion significantly improved phosphate clearance, although its effect on calcium clearance was less pronounced, suggesting that further research on continuous administration is warranted.
Background And Objective: During the coronavirus disease 2019 (COVID-19) pandemic, sedative prescriptions surged, leading to shortages of midazolam. This study investigates lormetazepam as an adjunct sedative alternative to midazolam for mechanically ventilated patients with COVID-19. We aimed to determine the clinical pharmacokinetics (PK) of enterally administered lormetazepam and provide dosing recommendations.
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- Sepsis can lead to acute kidney injury, requiring continuous kidney replacement therapy (CKRT), and this therapy can impact how drugs like cefepime are processed in critically ill children.
- Researchers conducted Monte Carlo simulations (MCS) to evaluate different dosing strategies of cefepime for children on CKRT, focusing on achieving desired drug concentrations against bacteria like Pseudomonas aeruginosa.
- They found that continuous infusions of cefepime resulted in a higher probability of reaching effective drug levels compared to other dosing methods, especially at higher doses and lower residual kidney function.
Objectives: To determine the frequency of early meropenem concentration target attainment (TA) in critically ill children with severe sepsis; to explore clinical, therapeutic, and pharmacokinetic factors associated with TA; and to assess how fluid resuscitation and volume status relate to early TA.
Design: Retrospective analysis of prospective observational cohort study.
Setting: PICU in a single academic quaternary care children's hospital.