Publications by authors named "N Presneau"
Article Synopsis
- Breast cancer patients with the CHEK2 c.1100delC variant have a heightened risk of developing a second breast cancer (contralateral breast cancer) and generally experience worse survival outcomes compared to those without the variant.
- A study involving over 82,000 women aimed to evaluate how the CHEK2 variant, radiotherapy, and systemic treatments affect the risk of contralateral breast cancer and breast cancer-specific survival.
- Findings indicated that while systemic therapy (especially the combination of chemotherapy and endocrine therapy) lowers the risk of contralateral breast cancer, CHEK2 c.1100delC carriers still faced poorer survival rates, suggesting other factors at play beyond the risk of developing a second cancer.*
Breast cancer (BC) patients with a germline c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers. We aimed to assess the associations of c.
View Article and Find Full Text PDFBackground: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.
Methods: We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls.
Article Synopsis
- - The study investigates the causal relationship between physical activity, sedentary behavior, and breast cancer risk using Mendelian randomization, analyzing data from over 130,000 European women.
- - Findings suggest that higher levels of genetic predisposition to physical activity are linked to a significantly lower overall breast cancer risk, particularly for pre/perimenopausal cases, while increased sedentary time correlates with a higher risk of certain types of tumors.
- - The results are consistent across various test groups and indicate that promoting physical activity and reducing sedentary behavior might be beneficial in mitigating breast cancer risks.