Decreasing the load? Is a Multidisciplinary Multistep Medication Review in older people an effective intervention to reduce a patient's Drug Burden Index? Protocol of a randomised controlled trial.

Introduction: Older people often use medications with anticholinergic or sedative side effects which increase the risk of falling and worsen cognitive impairment. The Drug Burden Index (DBI) is a measure of the burden of anticholinergic and sedative medications. Medication reviews are typically done by a pharmacist in collaboration with a general practitioner to optimise the medication use and reduce these adverse drug events.

[Psychotropic drugs dispensed on the island of Bonaire].

Background: Up till now little is known about psychiatric disorders in relation to the use of psychotropics drugs on the Dutch Antilles, with the exception of Curaçao.

Aim: To map the quantity and type of psychotropics prescribed for Bonairians in 2009.

Method: We performed a retrospective data analysis of the antipsychotics dispensed by the pharmacies on Bonaire in 2009.

The bioconversion process of deoxypodophyllotoxin with Linum flavum cell cultures.

The in vitro cell suspension culture of Linum flavum is able to convert high amounts of the 2,7'-cyclolignan deoxypodophyllotoxin into 6-methoxypodophyllotoxin 7- O-glucoside. We studied this conversion in detail by monitoring the intermediates and side-products after feeding different concentrations of deoxypodophyllotoxin. At a low concentration (0.

A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris.

In the roots of Anthriscus sylvestris 12 different lignans were detected. Arctigenin, dimethylmatairesinol, dimethylthujaplicatin, podophyllotoxin, 7-hydroxyyatein and 7-hydroxyanhydropodorhizol have not been previously reported to be present in A. sylvestris.

Determination of valepotriates.

In this paper an overview is given of qualitative and quantitative methods of analysis used for valepotriates. Methods like spectophotometry, titrimetry, TLC, GC, HPLC, MS, CE as well as p-SFC have been applied. Today HPLC is the method of choice.