Publications by authors named "N Prade"
B cell acute lymphoblastic leukemia (B-ALL) is a multistep disease characterized by the hierarchical acquisition of genetic alterations. However, the question of how a primary oncogene reprograms stem cell-like properties in committed B cells and leads to a preneoplastic population remains unclear. Here, we used the PAX5::ELN oncogenic model to demonstrate a causal link between the differentiation blockade, the self-renewal, and the emergence of preleukemic stem cells (pre-LSCs).
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- Germline mutations in the GATA2 gene increase the risk of developing myeloid cancers, particularly as patients acquire additional genetic mutations over time.
- An analysis of 78 patients revealed an exhaustion of myeloid progenitor cells and frequent somatic mutations in specific genes (STAG2, ASXL1, SETBP1) along with notable chromosomal abnormalities.
- Patients were categorized into three groups based on their bone marrow cell composition, with each group's mutations corresponding to their disease stage, indicating that understanding these mutations can improve patient management and illuminate cancer progression associated with GATA2 mutations.
A 3-year-old girl of nonconsanguineous healthy parents presented with cervical and mediastinal lymphadenopathy due to Mycobacterium fortuitum infection. Routine blood analysis showed normal hemoglobin, neutrophils, and platelets but profound mononuclear cell deficiency (monocytes < 0.1 × 109/L; B cells 78/μL; NK cells 48/μL).
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- * The study analyzed 113 cases of del(11q) MDS, highlighting features like a predominance in females, survival rates similar to other MDS cases, and a specific genetic deletion affecting key genes associated with hematopoiesis.
- * Findings suggest that the loss of the CADM1 gene, along with other genetic mutations, may play a significant role in the development of del(11q) MDS, indicating its potential as