Publications by authors named "N Popgeorgiev"
Article Synopsis
- Apoptosis is the primary regulated form of cell death in metazoans, but recent research indicates that both intrinsic and extrinsic apoptotic pathways vary among different groups, particularly in non-mammalian species.
- Despite being a significant group in metazoan evolution, lophotrochozoans have been under-studied in terms of apoptosis mechanisms, revealing gaps in understanding these pathways.
- A study analyzing initiator caspases and their evolution in lophotrochozoans showed notable diversification and loss of components in certain taxa, highlighting the complexity and variability of apoptotic pathways throughout metazoan evolution.
Apoptosis plays a role in cell homeostasis in both normal development and disease. Bcl-xL, a member of the Bcl-2 family of proteins, regulates the intrinsic mitochondrial pathway of apoptosis. It is overexpressed in several cancers.
View Article and Find Full Text PDFViruses infecting bacteria (bacteriophages) represent the most abundant viral particles in the human body. They participate in the control of the human-associated bacterial communities and play an important role in the dissemination of virulence genes. Here, we present the identification of a new filamentous single-stranded DNA phage of the family , named Ralstonia Inoviridae Phage 1 (RIP1), in the human blood.
View Article and Find Full Text PDFMembrane structural integrity is essential for optimal mitochondrial function. These organelles produce the energy needed for all vital processes, provided their outer and inner membranes are intact. This prevents the release of mitochondrial apoptogenic factors into the cytosol and ensures intact mitochondrial membrane potential (ΔΨ) to sustain ATP production.
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