Publications by authors named "N Poornagangadevi"
Background & Objectives: As India and other developing countries are scaling up isoniazid preventive therapy (IPT) for people living with HIV (PLHIV) in their national programmes, we studied the feasibility and performance of IPT in terms of treatment adherence, outcome and post-treatment effect when given under programmatic settings.
Methods: A multicentre, prospective pilot study was initiated among adults living with HIV on isoniazid 300 mg with pyridoxine 50 mg after ruling out active tuberculosis (TB). Symptom review and counselling were done monthly during IPT and for six-month post-IPT.
Article Synopsis
- The study focuses on long-term outcomes of ART in HIV-infected children from low and middle-income countries, analyzing data from 393 ART-naive children aged 2-12 who started treatment between 2010 and 2015.
- After 48 weeks, significant health improvements were noted, with nearly 90% of participants experiencing increased CD4 T cell counts, although immunologic and virologic failures were observed in 11% and 29% of children, respectively.
- The research highlighted a lack of correlation between immunologic and virologic failure, with multiple NNRTI mutations detected in children experiencing virologic failure, emphasizing the need for ongoing monitoring and adherence to ART.
Background: WHO recommends the use of a simplified symptom-based algorithm for screening for tuberculosis (TB) among people living with HIV (PLHIV). We assessed the feasibility and effectiveness of this algorithm and determined the prevalence and incidence of TB among PLHIV attending antiretroviral treatment (ART) centres in India.
Methods: We did a prospective multicentric implementation research study in four states of India.