[INFLUENCE OF COMBINED PHARMACOLOGICAL AND HYPOXIC PRECONDITIONING ON ANIMAL SURVIVAL AND FUNCTIONAL ACTIVITY OF CNS DURING MODEL CEREBRAL ISCHEMIA.].

The combined action of amthizole administration and hypoxia conditions on the survival of rats and the functional state of the central nervous system has been studied on a model of bilateral common carotid artery occlusion. It is established that this combined preconditioning produces cerebroprotective action, increases animal survival after surgery (estimated 72 h upon the onset of ischemia) by 38% (p = 0.029) in early and by 29% (p = 0.

Non-cyclic geometric phase of nuclear quadrupole resonance signals of powdered samples.

The non-cyclic geometric phase of ¹⁴N and ³⁵Cl NQR signals induced by the character of trajectory of nuclear magnetization motion upon pulse r.f. excitation of powdered samples is studied.

[Effect of antihypoxants on the consumption of oxygen in animals with traumatic brain injury].

The effect of drugs on the dynamics of oxygen consumption in experimental animals with traumatic brain injury (TBI) has been measured. It is established that the antihypoxants bemithyl, amtizole, trymeen, and ethomersol in a dose of 25 mg/kg decrease the consumption of oxygen and reduced oxygen demands of tissues in the acute posttraumatic period. These phenomena can play a significant role in the mechanism of the protective action of drugs under conditions of TBI.

[Effect of aminothiol anthihypoxants on hydration and peroxidation processes in traumatic brain injury].

The hydration (content of total, bound, and free water) and the activity of lipid peroxidation (LPO) processes in the brain have been studied in rats on the background of traumatic brain injury (TBI) dynamics. It is established that aminothiol-based anthihypoxants such as bemithyl and amthizol in a dose of 25 mg/kg alleviate changes induced by TBI. In particular, the drugs decrease the content of total and free water, increase the level of bound water, and inhibit the LPO intensity in the brain.

[Biological properties of bacteria of the species Shigella flexneri].

Some biological properties of S. flexneri have been studied. The strains of this bacterial species have been shown to produce DNAase in 98.