WHEN AND HOW IS SURGERY REQUIRED FOR LARGE ENDOMETRIOMA PRIOR TO IN VITRO FERTILIZATION (IVF): A SURVEY OF PRACTICES.

Introduction: Proper management of large endometriomas in patients scheduled for IVF continues to be a matter of debate. While small endometriomas are no longer an absolute indication for surgery, the large ones present unique challenges, potentially impacting ovarian response and follicle accessibility. This study aims to evaluate current practices among gynecologists in managing large endometriomas before IVF.

Intraoperative transvaginal ultrasound to standardize bowel endometriosis shaving.

Objective: To study the use of intraoperative transvaginal ultrasound after bowel endometriosis shaving.

Design: Stepwise demonstration with a narrated video footage of preoperative and intraoperative ultrasound to evaluate the extent of an endometriotic rectal nodule.

Setting: Lausanne University Hospital and Geneva University Hospital.

Why do oestrogens matter: systematic review and meta-analysis assessing GnRH antagonists, considering add-back therapy, for endometriosis-associated pain.

Gonadotrophin-releasing hormone (GnRH) antagonists have been demonstrated to reduce endometriosis-associated pain. Because of the hypo-oestrogenic state they induce, however, higher dosages of GnRH antagonists are not recommended for used long term. This unwanted effect may be eliminated by so-called add-back therapy (ABT).

Vitrification of human blastocysts for couples undergoing assisted reproduction: an updated review.

Over the past 40 years there has been a worldwide critical change in the field of assisted reproduction technology (ART), leading to the increased application of single blastocyst transfer, which is extremely important to avoid the risks of multiple pregnancy and associated complications for both mother and babies. Indeed, advancements in ART over the last few decades have been obtained thanks to several improvements, including ovarian stimulation, embryo culture conditions and, of course, progress in cryopreservation methods, especially with the application of vitrification. The ability to cryopreserve human embryos has improved significantly with vitrification compared to the initially adopted slow-freezing procedures.

Impact of semen microbiota on the composition of seminal plasma.

Several studies have found associations between specific bacterial genera and semen parameters. Bacteria are known to influence the composition of their niche and, consequently, could affect the composition of the seminal plasma. This study integrated microbiota profiling and metabolomics to explore the influence of seminal bacteria on semen metabolite composition in infertile couples, revealing associations between specific bacterial genera and metabolite profiles.