Publications by authors named "N Pittman"
Background: IgE-mediated food allergy and eosinophilic esophagitis (EoE) are diseases commonly triggered by milk. Milk-responsive CD4 T cells producing type 2 cytokines are present in both diseases, yet the clinical manifestation of disease in milk allergy (MA) and EoE are distinct.
Objective: We sought to identify differences in CD4 T cells between EoE and MA that may be responsible for distinct disease manifestations.
Article Synopsis
- - The study investigates the effectiveness of intestinal ultrasound (IUS) in predicting endoscopic remission (ER) in children with Crohn's disease (CD) undergoing biologic therapy as part of a treat-to-target (T2T) approach.
- - Results show that a decrease of 18% or more in bowel wall thickness (BWT) at week 8 strongly predicts endoscopic remission, demonstrating high accuracy with 100% sensitivity and 93% specificity.
- - The findings suggest that using IUS for early monitoring could enhance treatment optimization in CD patients, proving to be more effective than relying solely on clinical symptoms or C-reactive protein levels.
Background: Upadacitinib (UPA) is a novel selective JAK inhibitor approved for adults with ulcerative colitis (UC) and with positive phase 3 data for Crohn's disease (CD). Pediatric off-label use is common due to delays in pediatric approvals; real-world data on UPA are needed to understand the safety and effectiveness in pediatric IBD.
Methods: This is a single-center retrospective case series study of adolescents (12-17 years) with inflammatory bowel disease IBD on UPA.
Introduction: High rates of screen failure for the minimum Simple Endoscopic Score for Crohn's Disease (SES-CD) plague Crohn's disease (CD) clinical trials. We aimed to determine the accuracy of segmental intestinal ultrasound (IUS) parameters and scores to detect segmental SES-CD activity.
Methods: A single-center, blinded, cross-sectional cohort study of children and young adult patients with CD undergoing IUS and ileocolonoscopy, comparing segmental IUS bowel wall thickness (BWT), hyperemia (modified Limberg score [MLS]), and scores to detect segmental SES-CD activity: (i) SES-CD ≤2, (ii) SES-CD ≥6, and (iii) SES-CD ≥4 in the terminal ileum (TI) only.
We are 52 Black scientists. Here, we establish the context of Juneteenth in STEMM and discuss the barriers Black scientists face, the struggles they endure, and the lack of recognition they receive. We review racism's history in science and provide institutional-level solutions to reduce the burdens on Black scientists.
View Article and Find Full Text PDF