Guanidines Conjugated with Cell-Penetrating Peptides: A New Approach for the Development of Antileishmanial Molecules.

Leishmaniasis is a neglected tropical disease caused by a protozoan of the genus Leishmania, which has visceral and cutaneous forms. The symptoms of leishmaniasis include high fever and weakness, and the cutaneous infection also causes lesions under the skin. The drugs used to treat leishmaniasis have become less effective due to the resistance mechanisms of the protozoa.

'Despite the Pain, I Keep Moving Forward': A Qualitative Study on Brazilian Older Adults' Experiences With Chronic Low Back Pain.

Objective: The burden of chronic low back pain (CLBP) is increasing rapidly along with the global population ageing. Such an increase will occur more rapidly in low- and middle-income countries (LMICs). Yet, few studies have explored the experiences of older adults with CLBP, and these are primarily conducted in high-income countries.

Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy.

Background: Endothelin 1 receptors are one of the drivers of tumor progression in many cancers. Inhibition of their signaling pathways with antagonist drugs has been the subject of numerous clinical trials, but the results have not met expectations probably due to the high endothelin concentrations in the tumor microenvironment and their unusually high affinity for their receptors.

Methods: We previously reported the rendomab B49 antibody (RB49) exhibiting a preferential affinity for the activated conformation of human endothelin B receptor (ET), not displaced by high endothelin levels, and without any pharmacological properties that could inhibit the division of melanoma cells.

Unveiling degenerative bone changes in the condyle: a texture analysis approach using cone-beam computed tomography.

Purpose: The degenerative joint disease is a temporomandibular disorder. By analysing texture parameters, it becomes possible to characterize and differentiate various tissues, based on their textural properties according to cone-beam computed tomography (CBCT). This study evaluated degenerative diseases in the temporomandibular joint through texture analysis.

Digital Twin-Assisted Lightpath Provisioning and Nonlinear Mitigation in C+L+S Multiband Optical Networks.

Multiband (MB) optical transmission targets increasing the capacity of operators' optical transport networks. However, nonlinear impairments (NLI) affect each optical channel in the C+L+S bands differently, and, therefore, the routing and spectrum assignment (RSA) problem needs to be complemented with fast and accurate tools to consider the quality of transmission (QoT) within the provisioning process. This paper proposes a digital twin-assisted approach for lightpath provisioning to provide a complete solution for the RSA problem that ensures the required QoT in MB optical networks.