Publications by authors named "N Piette"
About 30 % of patients scheduled for surgery present with preoperative anemia. The presence of preoperative anemia increases the likelihood of exposure to allogenic blood transfusions, which carries specific complications. Furthermore, and independently of the transfusion risk, it is associated with an increased risk of postoperative morbidity and mortality.
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- DOCK8 deficiency is a serious immunodeficiency that can only be treated effectively through allogeneic hematopoietic cell transplantation (HCT), which was tested in a clinical trial using a busulfan-based regimen for its effectiveness and safety.
- The trial involved 36 patients (mostly children and young adults) and aimed to see if HCT could improve their health and immune system within one year, with many achieving over 98% donor chimerism shortly after treatment.
- Results showed 80.6% of participants were alive without new complications after a median follow-up of 7.4 years, and the treatment was generally well-tolerated, although some experienced immune system
Background: Oral as compared to intravenous tranexamic acid (TXA) is an attractive option, in terms of cost and safety, to reduce blood loss and transfusion in total hip arthroplasty. Exclusion criteria applied in the most recent randomised trials may have limited the generalisability of oral tranexamic acid in this indication. Larger and more inclusive studies are needed to definitively establish oral administration as a credible alternative to intravenous administration.
View Article and Find Full Text PDFBackground: Intraoperative hypothermia is associated with increased morbidity and impaired postoperative recovery. Direct anterior-approached total hip arthroplasty (ATHA) may lead to significant thermal loss. We aimed to assess whether preoperative warming had an impact on intraoperative hypothermia and postoperative functional recovery after ATHA.
View Article and Find Full Text PDFBackground: Pain after a posterolateral approach for total hip arthroplasty (THA) may affect early functional recovery. Supra-inguinal fascia iliaca (SFIB) and pericapsular nerve group (PENG) blocks have been proposed as promising analgesia techniques.
Objectives: This trial was conducted to compare a PENG with a SFIB for controlling postoperative pain and for providing functional recovery.