Publications by authors named "N Philippi"
The differential mechanisms between proteinopathies and neurodegeneration in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) remain unclear. To address this issue, we conducted a voxel-based morphometry and cerebrospinal fluid biomarker (α-synuclein, Aβ42, t-Tau and p-Tau) level correlation study in patients with DLB, AD and mixed cases (AD + DLB). Cerebrospinal fluid samples obtained by lumbar puncture and whole-brain T1-weighted images were collected in the AlphaLewyMA cohort.
View Article and Find Full Text PDFBackground: The use of cerebrospinal (CSF) biomarkers in the diagnosis of Alzheimer's disease (AD) has been gaining interest in clinical practice. Although their usefulness has been demonstrated, their potential value in older patients remains debated.
Objectives: To assess whether knowledge of the results of CSF AD biomarkers was associated with the same gain in diagnostic confidence in older adults > 80 than in younger patients.
Although deficits in learning and retrieving new information are well characterized in dementia with Lewy bodies, autobiographical memory has never been explored in this disease. Yet, autobiographical memory impairments are a pervasive feature of dementia, well characterized in other neurodegenerative diseases. Moreover, autobiographical memory corresponds to an extension over time of the self, which we hypothesize is altered in dementia with Lewy bodies and impairment of which could be linked to the insular atrophy occurring from an early stage of the disease.
View Article and Find Full Text PDFBackground: Dementia with Lewy Bodies (DLB) is responsible for cognitive-behavioural disorders but also for gait disorders. The latter are thought to be related to parkinsonism, but the neural bases of these disorders are not well known, especially in the early stages. The aim of this study was to investigate by volumetric Magnetic Resonance Imaging the neuronal basis of gait disorders in DLB patients, compared to Healthy Elderly Controls and Alzheimer's Disease patients.
View Article and Find Full Text PDFArticle Synopsis
- Research indicates that plasma biomarkers related to amyloid, tau, neurodegeneration, and neuroinflammation could be useful in diagnosing dementia, but their effectiveness for diagnosing dementia with Lewy bodies (DLB) specifically remains unclear.
- A study involving patients with DLB, Alzheimer's disease (AD), and neurological controls measured various plasma biomarkers and found that DLB patients had altered biomarker levels compared to controls and AD patients.
- Plasma p-tau181 was the most effective biomarker for distinguishing DLB from AD and controls, suggesting it plays a key role in identifying amyloid-related issues in DLB, although the overall diagnostic performance of these biomarkers was moderate.