Publications by authors named "N Pfennigwerth"

Article Synopsis
  • The study aimed to understand how a clinical isolate of carbapenem-resistant Pseudomonas aeruginosa resists treatment by investigating its carbapenemase mechanism.
  • Researchers conducted various tests, including phenotypic tests and whole-genome sequencing, to detect and characterize a new metallo-β-lactamase (MBL) gene, named NWM-1, which had not been documented before.
  • The findings emphasize the importance of whole-genome sequencing in discovering new antibiotic resistance mechanisms, highlighting the ongoing evolution of resistance in clinical bacteria.
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Infections with multidrug-resistant gram-negative bacterial species are a great concern in clinics in Germany. By limiting therapeutic options dramatically, these bacteria pose a significant threat to patient health and cause extensive pressure on hygiene systems and patient management. In Germany, the recommendations on how to deal with these bacteria are called MRGN classification, using the terms 3MRGN and 4MRGN for bacteria resistant to three or four major classes of antibiotics.

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Resistance to last-resort antibiotics is a global threat to public health. Therefore, surveillance and monitoring systems for antimicrobial resistance should be established on a national and international scale. For the development of a One Health surveillance system, we collected exemplary data on carbapenem and colistin-resistant bacterial isolates from human, animal, food, and environmental sources.

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BackgroundThe war in Ukraine led to migration of Ukrainian people. Early 2022, several European national surveillance systems detected multidrug-resistant (MDR) bacteria related to Ukrainian patients.AimTo investigate the genomic epidemiology of New Delhi metallo-β-lactamase (NDM)-producing from Ukrainian patients among European countries.

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