Publications by authors named "N Petejova"
Acute kidney injury due to gentamicin nephrotoxicity and specific miRNAs as biomarkers.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
October 2024
Article Synopsis
- Gentamicin, an antibiotic used to treat infections, can cause acute kidney injury (AKI) due to its nephrotoxic effects, especially in patients on high doses or long-term therapy.
- Researchers are exploring non-protein-coding RNAs, particularly microRNAs (miRNAs), as potential biomarkers for diagnosing and monitoring gentamicin-induced AKI.
- Changes in miRNA expression related to inflammation, cell death, and oxidative stress have been observed in response to gentamicin exposure, indicating their potential role in assessing kidney injury severity.
One of the common causes of acute kidney injury (AKI) is drug nephrotoxicity. A large group of drugs associated with AKI includes a considerable number of antimicrobials. Clinical manifestations range from mild forms of tubular damage to significant deterioration of renal function requiring renal replacement therapy.
View Article and Find Full Text PDFNew biomarker panel was developed and validated on 165 critically ill adult patients to enable a more accurate invasive candidiasis (IC) diagnosis. Serum levels of the panfungal biomarker (1,3)-β-D-glucan (BDG) and the inflammatory biomarkers C-reactive protein, presepsin (PSEP), and procalcitonin (PCT) were correlated with culture-confirmed candidemia or bacteremia in 58 and 107 patients, respectively. The diagnostic utility was evaluated in sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).
View Article and Find Full Text PDFBackground: Through regulation of signaling pathways, microRNAs (miRNAs) can be involved in sepsis and associated organ dysfunction. The aims of this study were to track the 7-day time course of blood miRNAs in patients with sepsis treated with vancomycin, gentamicin, or a non-nephrotoxic antibiotic and miRNA associations with neutrophil gelatinase-associated lipokalin (NGAL), creatinine, procalcitonin, interleukin-6, and acute kidney injury (AKI) stage.
Methods: Of 46 adult patients, 7 were on vancomycin, 20 on gentamicin, and 19 on another antibiotic.
Background: IgA nephropathy (IgAN) primary glomerulonephritis is characterized by the deposition of circulating immune complexes composed of polymeric IgA1 molecules with altered O-glycans (Gd-IgA1) and anti-glycan antibodies in the kidney mesangium. The mesangial IgA deposits and serum IgA1 contain predominantly light (L) chains, but the nature and origin of such IgA remains enigmatic.
Methods: We analyzed L chain expression in peripheral blood B cells of 30 IgAN patients, 30 healthy controls (HCs), and 18 membranous nephropathy patients selected as disease controls (non-IgAN).