Publications by authors named "N Pelletier"
Human exposure to polycyclic aromatic hydrocarbons (PAH) is a significant public health problem that will worsen with a warming climate and increased large-scale wildfires. Here, we characterize an epigenetic memory at the cytochrome P450 1 A (CYP1A) gene in wild Fundulus heteroclitus that have adapted to chronic, extreme PAH pollution. In wild-type fish, CYP1A is highly induced by PAH.
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- Researchers explored how combining DNA vaccination with a potent HBV neutralizing antibody might improve treatment for chronic HBV infections, which are hard to manage due to weak immune responses.
- In a study with mice, treatment with the antibody and a DNA vaccine led to the development of specific immune cells in the liver, enhancing immune recruitment but also indicating T cells became dysfunctional over time.
- While this combination therapy did not fully cure the infection, it showed promise by improving the immune response and providing insights into how the liver tolerates HBV.
Article Synopsis
- People are getting more exposed to harmful chemicals called PAH, especially because of climate change and wildfires.
- Some fish have adapted to live in waters with high PAH pollution, showing changes in their genes that help protect them from cancer.
- When those fish are raised in clean water, they can recover some of their protective gene responses, indicating that their adaptations come from environmental influences, not just their DNA.
Wolverines are facultative scavengers that feed near the top of terrestrial food chains. We characterized concentrations of mercury and other trace elements in tissues of wolverine from a broad geographic area, representing much of their contemporary distribution in northwestern North America. We obtained tissues from 504 wolverines, from which mercury was measured on muscle (n = 448), kidney (n = 222), liver (n = 148), hair (n = 130), and brain (n = 52).
View Article and Find Full Text PDFChronic hepatitis B (CHB) is a major global health challenge. CHB can be controlled by antivirals but a therapeutic cure is lacking. CHB is characterized by limited HBV-specific T cell reactivity and functionality and expression of inhibitory receptors.
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