Publications by authors named "N Pehlivanov"
Hepatitis B virus reactivation (HBVr) during and after immunosuppressive/immunomodulatory (IS/IM) therapy is associated with significant morbidity and mortality, including hepatic decompensation and acute liver failure. The risk of HBVr with IS/IM has been heterogeneous and often unpredictable. As a result, patients with active or previous HBV infection are often excluded from clinical drug trials of such agents.
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- - Immune checkpoint inhibitors (ICIs) are effective cancer treatments but can cause unique liver injuries known as immune-mediated liver injury caused by checkpoint inhibitors (ILICI), which differ from typical drug-induced liver injuries.
- - There is a lack of standardized best practices for managing ILICI during drug development, even though awareness and guidelines for these immune-related adverse effects are increasing.
- - This publication provides recommendations for monitoring, diagnosing, and managing ILICI in clinical trials, focusing on best practices related to liver test monitoring, detection, causality assessment, and treatment protocols.
Purpose: The natural history and outcome of patients with gastroparesis is not well known. The aim of this study was to identify the clinical or pathophysiological characteristics, if any, that may be helpful in predicting therapeutic response in this condition.
Methods: This is a retrospective study of a cohort of patients who presented to a tertiary referral center with symptoms suggestive of gastroparesis.
Interobserver variability affects investigations involving assessment of complex visual data, such as histopathology, radiology and motility. This study assessed interobserver variation for interpretation of antroduodenal manometry (ADM), as this has not been previously investigated. Thirty-five ADM recordings from children aged 0.
View Article and Find Full Text PDFBackground: The pathophysiological basis of diabetic gastroparesis is poorly understood, in large part due to the almost complete lack of data on neuropathological and molecular changes in the stomachs of patients. Experimental models indicate various lesions affecting the vagus, muscle, enteric neurons, interstitial cells of Cajal (ICC) or other cellular components. The aim of this study was to use modern analytical methods to determine morphological and molecular changes in the gastric wall in patients with diabetic gastroparesis.
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