Cyclophilin A as a Pro-Inflammatory Factor Exhibits Embryotoxic and Teratogenic Effects during Fetal Organogenesis.

The precise balance of Th1, Th2, and Th17 cytokines is a key factor in successful pregnancy and normal embryonic development. However, to date, not all humoral factors that regulate and influence physiological pregnancy have been completely studied. Our data here pointed out cyclophilin A (CypA) as the adverse pro-inflammatory factor negatively affecting fetal development and associated with pregnancy complications.

War in Ukraine and dialysis treatment: human suffering and organizational challenges.

In January 2021, there were 9648 patients in Ukraine on kidney replacement therapy, including 8717 on extracorporeal therapies and 931 on peritoneal dialysis. On 24 February 2022, foreign troops entered the territory of Ukraine. Before the war, the Fresenius Medical Care dialysis network in Ukraine operated three medical centres.

[Diagnostic errors in patients with giant-cell tumor, bone cyst and osteosarcoma].

The article contains diagnostic error analysis of 439 patients with giant-cell tumor (176), bone cyst (158) and osteosarcoma (105) aged 4-75 for theperiod of 1990-2015. Morphological investigation of surgical material taken from the pathological focus sowed that diagnostic errors in clinical and X-ray examinations comprised up to 40.6% in giant -cell cases, 37.

[The impact of the long-term exposure of industrial aerosols on clinical and functional indices of the broncho-pulmonary system in aluminum smelter workers].

It was found that the appearance of respiratory diseases among workers was established to be associated with the impact of aerosols with the complex chemical composition, exceeding corresponding MAC. Among respiratory diseases in workers there were detected predominantly chronic non-obstructive bronchitis - 59.15%, and chronic obstructive pulmonary disease (COPD) - in 35.

[Combined pathology of the upper gastrointestinal tract in children: current trends].

The article presents the current views and controversial issues problems comorbidity upper gastrointestinal tract in children and adolescents (gastroesophageal reflux disease and gastroduodenal diseases). Analyzed their own long-term observations, depending on the type of disease, severity of motor disorders, endoscopic and morphological picture, infection Helicobacter pylori. The possible options for the formation of gastroesophageal reflux disease in children and adolescents with gastroduodenal diseases.