Publications by authors named "N Paricio"
Article Synopsis
- Ovarian failure (OF) affects around 1% of women under 40, often with unknown causes, which complicates personalized treatment approaches and highlights the need for genetic research.
- A study of 150 women’s genetic data identified 18 genes with significantly higher rates of genetic variations (SNVs) in those with OF compared to controls, suggesting new biological insights into the condition.
- Experimental validation in fruit flies showed that six of these genes were linked to reduced fertility, and the analysis also identified disruptions in key biological pathways important for ovarian function.
Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with and Activity in Neurodegenerative Diseases.
J Med Chem
September 2024
Herein, we describe the design, synthesis, and biological evaluation of 15 + hybrids. These ligands are polyfunctionalized indole derivatives developed by juxtaposing selected pharmacophoric moieties of and to act as multifunctional ligands. Compounds and were identified as potent HDAC6 inhibitors (IC = 0.
View Article and Find Full Text PDFEvaluation of type 1 diabetes mellitus as a risk factor of Parkinson's disease in a Drosophila model.
J Exp Zool A Ecol Integr Physiol
October 2023
Diabetes mellitus (DM) is a chronic metabolic disease characterized by high blood glucose levels, resulting from insulin dysregulation. Parkinson's disease (PD) is the most common neurodegenerative motor disorder caused by the selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta. DM and PD are both age-associated diseases that are turning into epidemics worldwide.
View Article and Find Full Text PDFParkinson's disease (PD) is an incurable neurodegenerative disorder caused by the selective loss of dopaminergic neurons in the . Current therapies are only symptomatic and are not able to stop or delay its progression. In order to search for new and more effective therapies, our group carried out a high-throughput screening assay, identifying several candidate compounds that are able to improve locomotor ability in mutant flies (a model of familial PD) and reduce oxidative stress (OS)-induced lethality in -deficient SH-SY5Y human cells.
View Article and Find Full Text PDFParkinson's disease (PD) is the second most common neurodegenerative disease. Diabetes mellitus (DM) is a metabolic disease characterized by high levels of glucose in blood. Recent epidemiological studies have highlighted the link between both diseases; it is even considered that DM might be a risk factor for PD.
View Article and Find Full Text PDF