Representation of a perceptual bias in the prefrontal cortex.

Perception is influenced by sensory stimulation, prior knowledge, and contextual cues, which collectively contribute to the emergence of perceptual biases. However, the precise neural mechanisms underlying these biases remain poorly understood. This study aims to address this gap by analyzing neural recordings from the prefrontal cortex (PFC) of monkeys performing a vibrotactile frequency discrimination task.

Emergent perceptual biases from state-space geometry in trained spiking recurrent neural networks.

A stimulus held in working memory is perceived as contracted toward the average stimulus. This contraction bias has been extensively studied in psychophysics, but little is known about its origin from neural activity. By training recurrent networks of spiking neurons to discriminate temporal intervals, we explored the causes of this bias and how behavior relates to population firing activity.

Modulation of cortical slow oscillatory rhythm by GABA receptors: an in vitro experimental and computational study.

Key Points: We confirm that GABA receptors (GABA -Rs) are involved in the termination of Up-states; their blockade consistently elongates Up-states. GABA -Rs also modulate Down-states and the oscillatory cycle, thus having an impact on slow oscillation rhythm and its regularity. The most frequent effect of GABA -R blockade is elongation of Down-states and subsequent decrease of oscillatory frequency, with an increased regularity.

Dopamine reward prediction error signal codes the temporal evaluation of a perceptual decision report.

Learning to associate unambiguous sensory cues with rewarded choices is known to be mediated by dopamine (DA) neurons. However, little is known about how these neurons behave when choices rely on uncertain reward-predicting stimuli. To study this issue we reanalyzed DA recordings from monkeys engaged in the detection of weak tactile stimuli delivered at random times and formulated a reinforcement learning model based on belief states.