The protein phosphatase EYA4 promotes homologous recombination (HR) through dephosphorylation of tyrosine 315 on RAD51.

Efficient DNA repair and limitation of genome rearrangements rely on crosstalk between different DNA double-strand break (DSB) repair pathways, and their synchronization with the cell cycle. The selection, timing and efficacy of DSB repair pathways are influenced by post-translational modifications of histones and DNA damage repair (DDR) proteins, such as phosphorylation. While the importance of kinases and serine/threonine phosphatases in DDR have been extensively studied, the role of tyrosine phosphatases in DNA repair remains poorly understood.

Toward Food Sovereignty for Coastal Communities of Eastern Québec: Co-designing A Website to Support Consumption of Edible Resources from the St. Lawrence River, Estuary, and Gulf.

Despite the abundance and proximity of edible marine resources, coastal communities along the St. Lawrence in Eastern Québec rarely consume these resources. Within a community-based food sovereignty project, Manger notre Saint-Laurent ("Sustenance from our St.

[Peracute Diseases of the Esophagus - Bleeding from Esophageal Varices, Esophageal Varices].

Peracute Diseases of the Esophagus - Bleeding from Esophageal Varices, Esophageal Varices Due to a permanently increased portal venous pressure - usually due to infectious or ethyltoxic liver cirrhosis - varices can form in the lower esophagus due to expansion of the submucosal venous plexus. Acute bleeding from the esophageal varices is a life-threatening situation. In therapy, a distinction is made between primary prophylaxis of bleeding, control of acute bleeding and prevention of recurrent bleeding.

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Produce a French-Canadian translation of AMSTAR 2, affirm its content validity, and examine interrater reliability. Based on Vallerand's methodological approach, we conducted forward and parallel inverse-translations. Subsequently, an expert panel evaluated the translations to create a preliminary experimental French-Canadian version.

The Fukuda Stepping Test Is Influenced by a Concurrent Cognitive Task and Step Height in Healthy Young Adults: A Descriptive Study.

The Fukuda stepping test assesses spatial orientation in people with vestibular disorders. To standardize the test, it is important to know which factors influence the outcome. This study investigated the impact of two factors, a concurrent cognitive task and step height, on the Fukuda stepping test in healthy individuals.