Publications by authors named "N Pandeya"
Background: Understanding the factors influencing age at melanoma diagnosis by sex and anatomic site is crucial for developing effective prevention and early detection strategies. While previous research has highlighted sex-based differences in melanoma incidence by age and anatomic distribution, the underlying mechanisms remain unclear. We aimed to investigate sex-specific patterns in melanoma age at diagnosis across different anatomic sites and thickness categories, considering the potential influence of disease progression and detection rates.
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- A study investigated the link between skin screening/surveillance and increased melanoma diagnoses using data from over 10 million Australians over several years.* -
- The results showed that individuals who were screened or surveilled had significantly higher rates of skin biopsies, excisions for suspected melanoma, and confirmed melanoma compared to those who weren't.* -
- Findings suggest that increased skin detection activities can lead to higher levels of diagnostic events and melanoma incidence, indicating a robust correlation between screening practices and skin cancer outcomes.*
With over 1.5 million new cases annually, skin cancers are the most commonly diagnosed group of cancers worldwide. Among these, melanoma and keratinocyte cancers (KC), comprising squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), are predominant.
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- The study aimed to estimate melanoma incidence in Australia based on ancestry risk factors from 2006 to 2021, breaking down the data by sex and age groups.
- The research utilized melanoma incidence rates from the U.S. SEER database alongside Australian census data to model and analyze trends in melanoma rates by ancestry-based risk.
- Results indicated a decline in the proportion of high-risk ancestry individuals and a decrease in melanoma rates among younger age groups, likely due to reduced ultraviolet radiation exposure attributed to social and behavioral changes.
Importance: It is unknown whether germline genetic factors influence in situ melanoma risk differently than invasive melanoma risk.
Objective: To determine whether differences in risk of in situ melanoma and invasive melanoma are heritable.
Design, Setting, And Participants: Three genome-wide association study meta-analyses were conducted of in situ melanoma vs controls, invasive melanoma vs controls, and in situ vs invasive melanoma (case-case) using 4 population-based genetic cohorts: the UK Biobank, the FinnGen cohort, the QSkin Sun and Health Study, and the Queensland Study of Melanoma: Environmental and Genetic Associations (Q-MEGA).