Publications by authors named "N Paloian"
Article Synopsis
- X-linked hypophosphatemic rickets (XLH) is a rare genetic disorder marked by high levels of FGF-23 and phosphate loss in urine, leading to symptoms like short stature and bone deformities.
- Traditional treatment options caused nephrocalcinosis (NC) in many patients, raising concerns about the safety of phosphate supplementation, while the newer treatment burosumab blocks FGF-23 and is thought to potentially alter this risk.
- In a study of 13 XLH children treated with burosumab, only three developed NC, suggesting a need to further investigate the impact of current treatments on kidney health in XLH patients.
Article Synopsis
- In patients with X-linked hypophosphatemia (XLH), traditional treatments can lead to nephrocalcinosis, but the connections between XLH, its treatment, and kidney function are still unclear.
- A study analyzed kidney health in 196 children and 318 adults with XLH, with findings showing a significant prevalence of nephrocalcinosis, especially in children, and its association with reduced kidney function.
- Results indicated that nephrocalcinosis was common in both age groups, with children showing more symptoms related to kidney function compared to adults, highlighting the need for deeper understanding and monitoring of kidney health in XLH patients.*
Introduction: Although ultrasound (US) is the preferred first-line imaging for pediatric nephrolithiasis, CT may be necessary in cases of a nondiagnostic US or when US in not available. Utilization of dose reduction strategies in children undergoing CT for nephrolithiasis is not well described. We compared use of low-dose CT (LDCT) in children presenting to 2 pediatric centers.
View Article and Find Full Text PDFElectrolyte disorders are very common in the pediatric population. Derangements in serum sodium and potassium concentrations are among the most frequently seen given the risk factors and comorbidities unique to children. Pediatricians, in both outpatient and inpatient settings, should be comfortable with the evaluation and initial treatment of disturbances in these electrolyte concentrations.
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