Publications by authors named "N P Utyashev"
[Possibilities of stimulating epileptic seizures using deep stereo-EEG electrodes in presurgical diagnosis in patients with drug-resistant epilepsy].
Zh Nevrol Psikhiatr Im S S Korsakova
October 2024
Article Synopsis
- Electrical stimulation mapping with depth stereo-EEG electrodes is crucial for diagnosing drug-resistant epilepsy before surgery.
- Despite being utilized since the 1960s, there is no standardized protocol for this technique, leading to varying practices across different countries.
- The study reviews current opinions on the method's significance, compares different schools' methodological approaches, and assesses its effectiveness in pinpointing epileptogenic zones in patients.
[Surgical treatment of focal drug-resistant epilepsy associated with temporal lobe encephalocele].
Zh Vopr Neirokhir Im N N Burdenko
February 2024
Background: In recent years, temporal lobe encephalocele has become more common in patients with focal drug-resistant epilepsy. Despite available experience, there are still no clear recommendations for choosing the extent of surgery in these patients.
Objective: To evaluate the effectiveness of diagnosis and surgical treatment of focal drug-resistant epilepsy associated with temporal lobe encephalocele.
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults. Tissue reorganization at the site of the epileptogenic focus is accompanied by changes in the expression patterns of protein molecules. The study of mRNA and its corresponding proteins is crucial for understanding the pathogenesis of the disease.
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- Mesial temporal lobe epilepsy (TLE) is the most prevalent form of epilepsy, primarily treated through surgery, though relapses are common and invasive EEG methods to predict outcomes are complicated.
- A study focused on identifying microRNAs as potential biomarkers for predicting surgical outcomes in TLE patients, reviewing literature from several scientific databases using targeted keywords.
- Among the microRNAs analyzed, only miR-654-3p effectively differentiated between patients with favorable and unfavorable surgical outcomes, indicating a need for ongoing research into these biomarkers and consideration of various influencing factors in their study.
Modified posterior quadrant disconnection in surgical treatment of drug-resistant epilepsy in a patient with left temporal and occipital lobe malformation.
Zh Vopr Neirokhir Im N N Burdenko
December 2022
Unlabelled: Adults with large multilobar lesions of temporal, parietal and occipital lobes of the dominant hemisphere suffering from drug-resistant epilepsy were considered inoperable for a long time.
Objective: To demonstrate favorable postoperative outcome in a patient with massive periventricular heterotopia of the left temporal and occipital lobes complicated by drug-resistant epilepsy.
Material And Methods: We analyzed localization of the brain malformation (massive periventricular heterotopia) and its relationship with surrounding structures in a 38-year-old patient considering preoperative MRI, functional MRI and MR tractography data.