Novel Efficient Multistage Lead Optimization Pipeline Experimentally Validated for DYRK1B Selective Inhibitors.

In addition to general challenges in drug discovery such as the identification of lead compounds in time- and cost-effective ways, specific challenges also exist. Particularly, it is necessary to develop pharmacological inhibitors that effectively discriminate between closely related molecular targets. DYRK1B kinase is considered a valuable target for cancer-specific mono- or combination chemotherapy; however, the inhibition of its closely related DYRK1A kinase is not beneficial.

[Results of treatment of severe burns in the specialized intensive care unit].

The present work is based on the analyses of treatment of 512 patients (228 adults and 224 children) with severe, critical and subcritical thermal injuries in the period from 1998 till 2005. Significant increase of the prevalence of patients with severe and critical burns was revealed in the general structure of the burn traumatisms. There is suggestive decrease in lethality of such patients due to optimization of the intensive treatment methods.

[Peculiarities of wound infections in severe burns].

Infections in patients with burns remain as a one of the main unsolved problems. The present work is based on the analysis of the data obtained from the 642 patients with burns (adults and children) during 2000-2005. The staphylococcus infection is still the leading.

[Reactivation of persistent herpes virus infection as a factor of endogenous uveitis in children].

Two hundred and fifty-five children with endogenous uveitis, aged 2 months to 15 years, were examined. 73-93% of children were chronically infected by different viruses of the human herpes group; mycoplasmal past-infection was detected in only 13% of them and Chlamydia past-infection _ in 3.7% of them.