Dysfunction of membrane-receptor system of blood cells and kidney tissue in experimental diabetes mellitus.

The effect of streptozotocin-induced diabetes mellitus on some parameters of energy metabolism and functional status of cell membranes was studied in experiments on rats. It was found that the development of diabetes mellitus is associated with dramatic changes in the metabolism of blood cells and kidney tissue: inhibition of aerobic ATP synthesis, accumulation of lactate, uncoupling of oxidative phosphorylation, and development of lactic acidosis. Diabetes mellitus leads to restructuring of membrane lipids, changes in microviscosity, and suppression of insulin receptors and membrane-bound Na(+), K(+)-ATPase, and Ca(2+)-ATPase.

[Lipid-proteinic interaction in erythrocytie and placental membranes in women with insulin resistance].

Disturbances of erythrocyte and placental membrane functiond have been studied in placenta of pregnant women with obesity and diabetes mellitus type 2. The results of this study demonstrate significant metabolic impairments in women with insulin resistance. Changes in lipid spectrum of erythrocyte membranes and decreased activity of antioxidant enzymes obviously contribute to the development of fetoplacental insufficiency.

[Disfunction of membrane-receptor system of blood cells in children with diabetes mellitus of type I and II].

When metabolic failure in children and adolescents with diabetes, are violations of the structural and functional properties of membrane - the receptor apparatus of cells, accompanied by a decrease in ATP levels, inhibition of activity of membrane-bound enzyme Na+, K(+)-ATPase, a sharp decrease in insulin binding receptor activity and decrease glucose uptake by cells that indicates a decline in cell sensitivity to insulin. Diabetes in children and adolescents occurs with lipid disorders, activation of the processes of lipid peroxidation, manifested increasing concentrations of both primary and secondary products of lipid peroxidation, changes in structural and functional properties of erythrocyte membranes, as well as disturbances in the antioxidant defense system. Changes in the studied indexes depend on the type of diabetes and duration of the disease.

[Effect of mechanical oscillations in physiological solution on the contractile activity of the snail heart].

The effect of perfusate on the contractile activity of an isolated internally perfused heart of Helix pomatia was studied. The changes in heart activity induced by the switching of the perfusate stream were more pronounced in a potassium-free solution when the Na+, K(+)-pump was inactivated. It was found that the decrease in the amplitude of contractions of snail heart by acetylcholine (5.