Publications by authors named "N P Mendenhall"
Article Synopsis
- The study evaluates the use of mixed-reality (MixR) technology for patient setup in breast and chest wall radiotherapy, comparing it to traditional 3-point alignment methods in a clinical trial.
- In this trial involving 18 patients (10 for proton and 8 for photon therapy), alignment accuracy was measured using cone-beam CT imaging, with the MixR approach yielding similar accuracy to 3-point alignment.
- The findings suggest that MixR is feasible and can achieve comparable accuracy and efficiency; however, further advancements in technology and understanding are needed to fully optimize its effectiveness.
Purpose: Men with localized prostate cancer may receive either photon-based intensity modulated radiation therapy (IMRT) or proton beam therapy (PBT). The PARTIQoL trial (NCT01617161) demonstrates the feasibility of performing a large, multicenter phase 3 randomized trial comparing IMRT with PBT for localized prostate cancer. Here, we report baseline features of patients enrolled on this trial and present strategies to improve feasibility of other similar trials.
View Article and Find Full Text PDFPurpose: Radiation therapy (RT) causes cognitive deficits in pediatric brain tumor survivors (PBTS). Traditionally, this is measured using neuropsychological testing, which lack prediagnosis baseline and do not necessarily trigger action. This pilot project investigated a novel patient-centered outcome of scholastic performance using state-collected educational data.
View Article and Find Full Text PDFPurpose: In breast cancer, improved treatment approaches that reduce injury to lung tissue and early diagnosis and intervention for lung toxicity are increasingly important in survivorship. The aims of this study are to (1) compare lung tissue radiographic changes in women treated with conventional photon radiation therapy and those treated with proton therapy (PT), (2) assess the volume of lung irradiated to 5 Gy (V5) and 20 Gy (V20) by treatment modality, and (3) quantify the effects of V5, V20, time, and smoking history on the severity of tissue radiographic changes.
Patients And Methods: A prospective observational study of female breast cancer patients was conducted to monitor postradiation subclinical lung tissue radiographic changes.