De novo and inherited dominant variants in U4 and U6 snRNAs cause retinitis pigmentosa.

The U4 small nuclear RNA (snRNA) forms a duplex with the U6 snRNA and, together with U5 and ∼30 proteins, is part of the U4/U6.U5 tri-snRNP complex, located at the core of the major spliceosome. Recently, recurrent variants in the U4 RNA, transcribed from the gene, and in at least two other genes were discovered to cause neurodevelopmental disorder.

Diagnosis of spp. in ruminants at Southern Brazil.

spp. is a flagellated protozoan that parasitizes the small intestine of various mammals, birds, and amphibians, being transmitted via the fecal-oral route. Giardiasis is one of the most prevalent parasitic diseases in both developed and developing countries, with a prevalence of 0,1-5% and 20-30%, respectively, and is correlated with poor hygiene practices, such as irregular handwashing, which consequently contaminates food when handled.

Analyzing and mitigating the risks of patient harm during operating room to intensive care unit patient handoffs.

Patients continue to suffer from preventable harm and uneven quality outcomes. Reliable clinical outcomes depend on the quality of robust administrative systems and reliable support processes. Critically ill patient handoffs from the operating room (OR) to the intensive care unit (ICU) are known to be high-risk events.

Developing an HIV-specific falls risk prediction model with a novel clinical index: a systematic review and meta-analysis method.

Background: Falls are a common problem experienced by people living with HIV yet predictive models specific to this population remain underdeveloped. We aimed to identify, assess and stratify the predictive strength of various physiological, behavioral, and HIV-specific factors associated with falls among people living with HIV and inform a predictive model for fall prevention.

Methods: Systematic review and meta-analysis were conducted to explore predictors of falls in people living with HIV.

Hippocrepis fuelleborni (Digenea: Notocotylidae) from Argentina, morphological, molecular and phylogenetic studies.

Notocotylidae is a family with a cosmopolitan distribution, with 13 genera parasitizing birds and mammals. Four of these genera were registered in the Americas, and two parasitizing rodents in Argentina. In this paper, specimens of the genus Hippocrepis parasitizing Holochilus brasiliensis from Argentina are studied on the basis of morphological and molecular characteristics.