Publications by authors named "N P Kriek"
Article Synopsis
- Multiple myeloma (MM), smoldering myeloma (SM), and monoclonal gammopathy of undetermined significance (MGUS) can cause increased blood clot risks, but the reason why is not fully understood.
- A study looked at how a treatment called Lenalidomide affects platelets (the parts of blood that help it clot) in patients with these conditions compared to healthy people.
- The results showed that patients had more reactive platelets, meaning their blood was more likely to clot, especially after taking Lenalidomide; this suggests that further research is needed to understand the clotting issues better and find ways to prevent them.
Article Synopsis
- - This study investigates the role of platelet factor XIII-A (FXIII-A) in enhancing platelet function and activation during blood clotting, highlighting its significance beyond traditional antifibrinolytic roles.
- - The research uses normal platelets and FXIII-deficient platelets to analyze how FXIII-A affects fibrinogen binding, platelet aggregation, and clot retraction in blood samples, revealing that FXIII-A is critical for optimal platelet response to stimuli.
- - Findings indicate that the absence of FXIII-A diminishes platelet activation and spreading, leading to weaker clot formation and retraction, emphasizing the enzyme's essential contribution to effective thrombus formation.
Article Synopsis
- Platelet function varies widely among individuals, and current tests typically measure only the end-point activation levels without considering how quickly platelets activate, which might overlook important details about their reactivity.
- A new real-time flow cytometry method was developed to assess the speed of platelet activation, identifying distinct rates of response to different activating agents that do not necessarily relate to maximum activation levels.
- Findings show that faster platelet responses correlate with larger and denser blood clots in arterial conditions, suggesting that the activation rate should be considered in future antiplatelet therapies to enhance effectiveness while minimizing bleeding risk.
Objectives: Complex regional pain syndrome (CRPS) is a chronic debilitating disease characterized by sensory abnormalities. Spinal cord stimulation (SCS) is an effective therapy for CRPS, but few studies have investigated the effects of SCS therapy on sensory characteristics. Therefore, this study investigated the effect of SCS on allodynia, hyperalgesia, electrical quantitative sensory testing (QST) parameters, and conditioned pain modulation (CPM) effect.
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