Neurophysiological patterns of search and creative behavior in patients with psychoactive substance-induced disorders.

The correlation between search and creative behavior with parameters of bioelectric brain activity was observed in patients with addictive disorders. The prevalence of α- and θ-activities in the parietal-temporal-occipital areas of the cortex and increased θ-activity in the right hemisphere in addiction patients with high search and creative activities were associated with enhanced high-frequency activity in these brain areas. These changes can reflect the formation of a focus of pathologically increased excitation related to the pathogenic mechanisms of addictive disorders.

BMP-2 expression correlates with local failure in head and neck squamous cell carcinoma.

Objective: Preclinical data show that exogenous administration of recombinant human bone morphogenetic protein-2 (rhBMP-2) to human oral carcinoma cell lines increases pathogenicity using a nude mouse model. The objectives of this study are to (1) describe the characteristics of baseline protein expression of BMP-2 in head and neck squamous cell carcinomas (HNSCC) and (2) determine if BMP-2 expression level correlates with worse oncologic outcomes.

Study Design: Retrospective analysis of previously harvested patient samples.

[EEG features during olfactory stimulation in drug dependence persons].

Power spectra analysis EEG was used for baseline interval and during olfactory stimulation in drug dependence and healthy persons. Intergroup differences of EEG spectra were related with enhancement of cortex biopotential power in narcological patients at parietal and temporal sites. Interhemispheres features of frequency bands contribution in EEG spectra were identified.

PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells.

Programmed cell death-2 (PDCD2) protein is enriched in embryonic, hematopoietic, and neural stem cells, however, its function in stem/progenitor cell differentiation is unclear. We investigated the effects of PDCD2 knockdown on the development and differentiation of hematopoietic progenitor cells (HPC). CD34(+) cells derived from normal human bone marrow and K562 leukemic cells were effectively transduced with short-hairpin RNA to knockdown PDCD2.

Treatment effects of rhBMP-2 on invasiveness of oral carcinoma cell lines.

Objective: To determine if recombinant human bone morphogenetic protein-2 (rhBMP-2) has biological effects on the invasiveness of human oral squamous cell carcinoma (OSCCA) cell lines.

Study Design: Laboratory investigation using six human OSCCA cell lines, with three cell lines having baseline gene expression of BMP-2 and three cell lines without baseline gene expression of BMP-2.

Methods: The invasiveness of each cell line was measured using a matrigel invasion assay with or without stimulation by rhBMP-2.