Publications by authors named "N P Fisker"
Article Synopsis
- Varicella zoster virus (VZV) causes chickenpox and shingles, and can lead to severe complications like encephalitis and pneumonitis, particularly in vulnerable individuals.
- A case study of a 3-year-old boy showed a complex progression of varicella with serious symptoms, leading to the suspicion of hemophagocytic lymphohistiocytosis (HLH), which was treated despite ongoing issues.
- The patient had a rare genetic variant in the AMFR gene affecting immune response signaling, resulting in higher VZV replication and impaired immune function, highlighting the importance of the AMFR-STING pathway in fighting viral infections.
Background: Studies on the association between breastfeeding and infections in children beyond the first year of life reveal conflicting results. In a population-based birth cohort, we investigated whether the duration of breastfeeding was associated with the number of hospitalizations due to infection and symptoms of infection at home.
Methods: In the Odense Child Cohort, text message questionnaires were used to register information on breastfeeding (weekly until end of weaning) and symptoms of infection (biweekly; 12-36 months of age).
Background: STK4 deficiency due to homozygous mutations in the STK4 gene encoding the STK4/MST1 kinase was first described in 2012. STK4/MST1 kinase regulates cell proliferation, survival, differentiation, and immune responses through canonical and non-canonical Hippo signaling pathways.
Objective: We describe an 11-year-old girl with a clinical presentation consisting of severe recurrent herpes zoster, chronic warts, and recurrent pneumonias, as well as a somatic phenotype with hypothyroidism and low stature.
Background: The season in which a child is born may affect the immune system development and thereby influence the risk of infections. In this study, we examined the associations between birth season and the risk of hospital admission or symptoms associated with a wide range of infections.
Methods: This study is a prospective cohort study of 2434 children with an average follow-up of 3.