Publications by authors named "N P Campbell"
Article Synopsis
- The study examines long-term opioid therapy (LTOT) in older adults (≥ 65 years) utilizing Medicare claims data from 2014-2016.
- Around 6.3% of the participants were found to be on LTOT, with significant links to age (especially over 85), having multiple health conditions, and substance use history.
- Other factors influencing LTOT included the type of initial opioid prescribed (like long-acting opioids) and the length of the initial prescription, with longer supplies greatly increasing the likelihood of continuing opioid use.
Objectives: The Integrating Clinical Trials and Real-World Endpoints (ICAREdata) project aimed to demonstrate that electronic health record (EHR) data, expressed in a standard structured format, can be extracted and transmitted to contribute to clinical research. Using the minimal Common Oncology Data Elements (mCODE), we collected standardized oncology outcome data from EHRs across 10 clinical sites and 15 trials. This report details and assesses the ICAREdata technical implementation and offers recommendations to benefit future projects with similar goals.
View Article and Find Full Text PDFThe excision of specific tRNA-derived small RNAs (tsRNAs), yRNA-derived small RNAs (ysRNAs) and ribosomal RNA-derived small RNAs (rsRNAs) is now well established. Several reports have suggested many of these fragments function much like traditional microRNAs (miRNAs). That said, whereas the expressions of the majority of appreciably expressed miRNAs in HCT116 colon cancer cells are significantly decreased in individual knockouts (KOs) of DROSHA, DGCR8, XPO5, and DICER, on average, only 3.
View Article and Find Full Text PDFBackground: A digital adaptation of the nine-hole peg test (9HPT) was developed with the potential to provide novel disability features for patients with multiple sclerosis (PwMS).
Objectives: The objectives were to evaluate the 9HPT features based on reliability, prognosis, and discrimination between treatment groups.
Methods: The MS partners Advancing Technology and Health Solutions (MS PATHS) cohort data were used to derive new features including completion time and speed.