Publications by authors named "N P Boĭchenko"
Article Synopsis
- - The study explores how the compound Ac-Lys-Lys-Lys-NH (Ac-KKK-NH) binds to the Na1.8 channel, which plays a key role in encoding pain signals in the peripheral nervous system, using both experimental and theoretical techniques.
- - Experimental results show that when Ac-KKK-NH is applied at a concentration of 100 nM, it significantly reduces the effective charge of the Na1.8 channel's activation gating, and it exhibits strong analgesic effects in pain tests conducted in live animals.
- - Conformational analysis reveals that the distances between positively charged groups in Ac-KKK-NH are 11-12 Å, and docking studies identify its binding site on the voltage-sensing
The temporal structure of sound such as in music and speech increases the efficiency of auditory processing by providing listeners with a predictable context. Musical meter is a good example of a sound structure that is temporally organized in a hierarchical manner, with recent studies showing that meter optimizes neural processing, particularly for sounds located at a higher metrical position or strong beat. Whereas enhanced cortical auditory processing at times of high metric strength has been studied, there is to date no direct evidence showing metrical modulation of subcortical processing.
View Article and Find Full Text PDFUsing the framework of the Native Cancer Registry, cancer morbidity among Russian Inuit can be obtained from 1960 onwards. Earlier data are available, but have not been verified. Unfortunately, the absence of accurate demographic data for the Native population of about 16 000 people, including the increase from 1 149 to 1 452 Inuit between 1970 and 1989 prevents comparison and analysis of morbidity and mortality data with the non-Inuit population.
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