[Hypolipidemic effect of gevilon].

The drug gevilon that produces hypolipidemic effects has been clinically tested. The drug was used to treat 53 patients suffering from coronary heart disease, hypertensive disease with severe lipid metabolic disturbances. Gevilon has been found to have a hypolipidemic effect in reducing the levels of total cholesterol, beta-cholesterol, triglycerides, increasing alpha-cholesterol levels and normalizing the atherogenicity coefficient.

[Phosphocreatine in the treatment of patients with myocardial infarct: effects on hemodynamics and oxygen supply].

Changes in the major parameters of central and intracardiac hemodynamics and body's oxygen supply were examined in 93 patients with massive myocardial infarction in the in-hospital period of the disease. Traditional therapy was given to 71 patients; in addition, phosphocreatine infusions (a course dose being 30 g) were used in 22 patients in acute myocardial infarction. Phosphocreatine therapy failed to substantially affect cardiac pump function, but prevented left ventricular dilation and development of congestive heart failure.

[Possible approaches to an analysis of the heterogeneous response of the transcription complex to cholinergic actions].

The accumulation of tyrosine-aminotransferase (TAT) as a marker of the individual gene activation was studied in the rat tissue after the administration of cholinomimetics and cholinolytics in order to elucidate the relations between cholinoreceptor functional state and the genetic apparatus. The regulation of TAT synthesis was found to be controlled by both cholinomimetic concentration and the density of cholinoreceptors in hepatocytes. Transsynaptic regulation of TAT activity was shown to be different in the brain and liver.

[Diagnostic value of individual tests for classification of Shigella].

A total of 1243 strains of enterobacteria were studied by four tests (mobility, lysis with dysentery polyvalent bacteriophage, relation to Christensen's citrate and salicin) for the purpose of determining shigellae genera. A combination of signs characteristic of Shigella genus was observed in 99.1% of laboratory and in 100% of freshly-isolated strains.