Publications by authors named "N P"
Introduction: A series of benzylidene derivatives of fenobam and its thio analogues (1-22) have been evaluated for their cytotoxicity against breast cancer (MCF-7, MDA-MB-231), ovarian cancer (A2780, SKOV-3) and cervical cancer (HELA) cell lines.
Method: These compounds (1-22) exhibited 72-83% inhibition of Erk activity against the ovarian cancer cell line (A2780). Compounds 3 and 20 showed the highest DNA damage effect in Comet Assay against the A2780 cancer cell line as compared to the other tested analogues (4, 8, 11, 12, and 13) by using % Tail DNA and OTM.
Article Synopsis
- The abdomen is commonly affected in trauma cases, with blunt trauma being more dangerous than penetrating trauma, often leading to serious outcomes.
- Diagnostic challenges in blunt abdominal trauma can result in delayed treatment, increasing the risk of morbidity and mortality, especially for hollow viscus and mesenteric injuries.
- A case study highlights a 48-year-old male with a mid-ileal mesenteric tear and perforation who was treated successfully after a 96-hour delay post-injury through laparotomy and primary anastomosis.
The pulmonary drug delivery system is a promising and evolving technology in which the prescribed medicine is breathed through the lungs, and subsequently, it enters the circulation via the alveolar epithelium. This category of pulmonary drug delivery system is an appealing and non-invasive administration method. Pulmonary drug delivery is most commonly utilized to treat airway problems by providing locally active medicines directly to their site of action.
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