Publications by authors named "N Osterrieder"
Feline infectious peritonitis (FIP) is a lethal, immune-mediated disease in cats caused by feline infectious peritonitis virus (FIPV), a biotype of feline coronavirus (FCoV). In contrast to feline enteric coronavirus (FECV), which exclusively infects enterocytes and causes diarrhea, FIPV specifically targets macrophages, resulting in the development of FIP. The transmission and infection mechanisms of this complex, invariably fatal disease remain unclear, with no effective vaccines or approved drugs for its prevention or control.
View Article and Find Full Text PDFArticle Synopsis
- Monkeypox virus (MPXV) is a zoonotic virus that causes skin lesions in humans and is currently spreading globally, particularly its clade IIb strain from a 2022 outbreak.
- A study was conducted on domestic pigs where some were inoculated with the MPXV clade IIb isolate, revealing that both infected pigs and sentinel controls developed minor lesions, but no infectious virus was isolated.
- The research demonstrates that domestic pigs can be experimentally infected with MPXV and are capable of transmitting the virus to other animals, marking a significant finding in understanding the virus's host range.
Rapid evolution of highly pathogenic avian influenza viruses (HPAIVs) is driven by antigenic drift but also by reassortment, which might result in robust replication in and transmission to mammals. Recently, spillover of clade 2.3.
View Article and Find Full Text PDFThe development of effective SARS-CoV-2 vaccines has been essential to control COVID-19, but significant challenges remain. One problem is intramuscular administration, which does not induce robust mucosal immune responses in the upper airways-the primary site of infection and virus shedding. Here we compare the efficacy of a mucosal, replication-competent yet fully attenuated virus vaccine, sCPD9-ΔFCS, and the monovalent mRNA vaccine BNT162b2 in preventing transmission of SARS-CoV-2 variants B.
View Article and Find Full Text PDFIn this study, we applied bacterial artificial chromosome (BAC) technology with PRV as the base material to replace the first, central, and terminal segments of the US3 gene with codon-deoptimized fragments via two-step Red-mediated recombination in GS1783 cells. The three constructed BACs were co-transfected with gI and part of gE fragments carrying homologous sequences (gI+gE'), respectively, in swine testicular cells. These three recombinant viruses with US3 codon de-optimization ((PRV, PRV, and PRV) were obtained and purified.
View Article and Find Full Text PDF