Publications by authors named "N Orzes"

Article Synopsis
  • Lung cancer remains the leading cause of cancer mortality, but advancements in treating non-small cell lung cancer (NSCLC) have improved patient outcomes through tailored approaches using immune checkpoint inhibitors and genetic testing.
  • A study was conducted across multiple pulmonary pathology units in Northern Italy, analyzing biomarker testing data for 1,817 NSCLC patients over 24 months, finding that while most had at least one test, only 36% of advanced cases underwent all five recommended tests.
  • The results emphasize the need for comprehensive biomarker testing, as many early-stage patients also exhibited relevant genomic alterations, which is important for future targeted therapies.
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Background: The evaluation of COVID-19 systemic consequences is a wide research field in which respiratory function assessment has a pivotal role. However, the available data in the literature are still sparse and need further strengthening.

Aim: To assess respiratory function 4-6 months after hospital discharge based on lung disease severity in patients who overcome COVID-19 pneumonia.

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Objective: This study investigated the consequences of Coronavirus Disease 2019 (COVID-19) pneumonia on lung function in the first 6 months after hospital discharge.

Methods: A prospective lung function assessment in SARS-CoV2 patients with COVID-19 pneumonia, hospitalized between March and April 2020, was conducted with spirometry measurements including lung volumes, mainly total lung capacity (TLC), lung diffusion capacity for carbon monoxide (DL) collected at 3 months after hospital discharge. Patients with restrictive ventilatory defect or impaired DL or both were re-evaluated at 6 months with global spirometry and chest HRCT scan.

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Angiosarcoma is a rare malignancy of vascular origin, mostly originating from skin, soft tissues, and breast, but rarely also from the pleura. We present the case of a 55-year-old man who referred to our hospital for a spontaneous bilateral hemothorax. The CT angiography did not show any source of active bleeding; plus, no pleural or lung masses were observable.

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Rationale: Patients with chronic obstructive pulmonary disorder (COPD) complain of various COPD-related symptoms with different daily frequencies. During the night-time and at early morning, dyspnea is often reported and may predict an increased risk of COPD exacerbation and hospitalization and all-cause mortality. The aim of the study was to assess the underlying mechanisms of this symptom, seeking functional biomarkers of its occurrence.

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