Publications by authors named "N Okiyama"
Article Synopsis
- - This study compared juvenile idiopathic inflammatory myopathy (IIM) and adult-IIM by analyzing autoantibodies, clinical characteristics, and drug-free conditions in 320 patients over 20 years.
- - Juvenile-IIM showed a higher rate of achieving drug-free conditions (34%) compared to adult-IIM (18%), with specific autoantibodies like anti-TIF1-γ linked to fewer muscle symptoms and lower malignancy rates in juveniles.
- - Both groups had overlapping features with certain autoantibodies (like anti-MDA-5 and anti-ARS) associated with severe symptoms and a low likelihood of drug-free conditions, while treatment patterns differed notably between the two age groups.
A case of vesiculobullous dermatomyositis with anti-NXP-2 antibody without malignancy.
Mod Rheumatol Case Rep
January 2025
Vesiculobullous dermatomyositis (VD) is a rare manifestation of dermatomyositis (DM) and has been suggested to be associated with malignancy. Although the myositis-specific autoantibodies are associated with distinct clinical presentations of DM, those associated with VD remain unclear. Here, we present the case of a 54-year-old man with VD who tested positive for antinuclear matrix protein 2 (NXP-2) antibodies, one of the DM-specific autoantibodies.
View Article and Find Full Text PDFAnti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM) is characterized by amyopathic DM with interstitial lung disease (ILD). Patients with anti-MDA5 antibody-associated ILD frequently develop rapidly progression and present high mortality rate in the acute phase. Here, we established a murine model of ILD mediated by autoimmunity against MDA5.
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