Synthesis and in vitro evaluation of antibacterial and antibiofilm activities of novel triphenylphosphonium-functionalized substituted pyrimidines.

The increase in the prevalence of antibiotic-resistant pathogens leads to a decrease in the number of antimicrobial agents for the treatment of infections and prompts researchers to search for new effective antimicrobial drugs. This study reports the synthesis of novel triphenylphosphonium-functionalized substituted pyrimidines and in vitro evaluation of their antibacterial and antibiofilm activity. Most of the synthesized derivatives showed high antibacterial activity (MIC = 0.

[Prospects of antimicrobial drugs development on the basis of new synthetic substances].

The literature data concerning different chemical substances effects on microorganisms is considered in this paper. Synthetic substances screening is one of the promising ways of searching for new highly effective antimicrobial drugs. Previously those synthetic substances were not used in the clinical practice separately or in combinations as pharmacological products.

[Therapeutic efficacy of 4-(adamantyl-1)-1-(1-aminobutyl) benzene in experimental fungal pathology].

Antifungal activity of an adamantane derivative, i. e. 4-(adamantyl-1)-1-(1-aminobutyl) benzol was studied in experiments in vivo in a model of generalized infection and local skin injury.

[Antimicrobial effect of 4-(adamantyl-1)-1-(1-aminobutyl)benzol].

Antimicrobial activity in vitro of adamantine derivative in respect of aerobic and anaerobic microorganisms has been studied. In these conditions Gram-positive bacteria and some representatives of Gram-negative microorganisms (Shigella flexneri, S. newvcastle, Enterobacter aerogenes etc.