[Immunogenetic blood markers as a risk factor of development of periodic disease in Armenian population].

Aim: To reveal characteristic associations between various markers of immunogenetic (HLA--A, B, C, DR), erythrocytic (ABO, Rh-Hr, MNSs, Pp, Kell-Chellano, Lewis), serum (Gm, Inv) systems and familial Mediterranean fever (FMF) in Armenian population.

Material And Methods: From 41 to 125 patients (depending on systems studied) were examined. HLA-antigens of A-, B-, C-classes were detected by the microcytotoxic test in a total population of lymphocytes, HLA-DR antigens--by a prolonged test in B-lymphocytes, erythrocytic antigens--by hemagglutination technique and indirect Coombs' reaction, serum antigens--by the method of hemagglutination suppression.

[Distribution of HLA antigens in the armenian population of Nagornyi Karabakh].

Characteristics of the distribution of 31 HLA antigens of classes I (A, B, and Cw) and II (DR) in Nagornyi Karabakh Armenians are reported for the first time. It has been found that the antigens most common in this population are A2, A3, A9, B5, B7, B12, Cw4, DR4, DR2, and DR3; the least common antigens are B15, B16, and B40. The results are compared with the data for Armenians living in Armenia and those for major ethnic groups.

[Immunogenetic markers of erythrocyte systems in Armenians of Nagorniĭ Karabakh].

Frequencies of antigens of erythrocytic systems Rh-Hr, MNSs, Pp, Kidd, Duffy, Kell-Chellano, and Lewis were studied in the indigenous Armenian population of Nagornyi Karabakh with regard to all possible genotypes. The results were compared with those obtained for populations of the Caucasus, Europe, and Asia. In general, the studied population had a typical Caucasoid gene system.

[An analysis of the associational connections of immunogenetic blood markers with lymphogranulomatosis in Armenians].

A study of 11 immunogenetical blood systems (HLA-A, B C, DR; ABO; Rh-Hr; MNSs; Kidd; Kell-Chellano; Duffy; Lewis; Diego; Gm; Inv) involving 59 antigens was performed in patients of Armenian nationality with lymphogranulomatosis (LGM). Pathogenic associations of HLA, MNSs and Duffy systems with LGM were established. Positive correlations were found (p < 0.

[Necessity for immunologic studies in blood transfusion therapy].

162 samples of blood from sensitized patients were investigated immunohematologically. All the patients were in need of blood transfusions. Immunization to HLA-antigens, to leukocyte and erythrocyte antigens was found in 74.