Publications by authors named "N O Ku"
Background: Despite recent advances and global improvements in sepsis recognition and supportive care, mortality rates remain high, and adherence to sepsis bundle components in Korea is low. To address this, the Korean Sepsis Alliance, affiliated with the Korean Society of Critical Care Medicine, developed the first sepsis treatment guidelines for Korea based on a comprehensive systematic review and meta-analysis.
Methods: A de novo method was used to develop the guidelines.
Background: We aimed to assess the incidence of infective endocarditis (IE) and evaluate the impact of hypertension (HTN) with underweight on the risk of IE among patients with diabetic mellitus (DM) using a nationwide population-based cohort in Korea.
Methods: We identified 2,603,012 participants (57.4 ± 12.
Article Synopsis
- The study examined how weight changes in diabetic patients affect the risk of developing infective endocarditis (IE).
- It involved over 1.7 million patients, assessing weight variations and their correlation with IE occurrences during a follow-up period.
- Findings showed that both significant weight loss and weight gain increase the risk of developing IE, with more extreme changes leading to higher risk levels.
Article Synopsis
- Renal replacement therapy (RRT) is critical for treating sepsis-related acute kidney injury (AKI), but its ideal timing is debated; this study focused on the effects of starting continuous kidney replacement therapy (CKRT) within 6 hours of AKI onset.
- Analyzing data from the MIMIC-IV database, the study found that patients who received early CKRT had a significantly lower 28-day mortality rate compared to those who started later (26.7% vs. 43.9%).
- Additionally, early CKRT patients experienced more days without needing mechanical ventilation or vasopressors, indicating better overall clinical outcomes despite no significant difference when comparing CKRT initiation within 12 hours versus later.
Article Synopsis
- A study investigated the long-term effects of COVID-19 on lymphoma patients to understand the frequency, risk factors, and mortality associated with prolonged COVID-19.
- Among 583 lymphoma patients analyzed, 19.7% were diagnosed with COVID-19, with 24 of those experiencing prolonged symptoms, particularly linked to specific treatments like rituximab after bendamustine and rituximab therapy.
- Prolonged COVID-19 significantly increased the risk of hospitalization and was identified as an independent risk factor for higher mortality within a year.