[Gastroduodenal ulcers in the practice of joint endoprosthesis].

The gastroduodenal ulcer rate and the gastrointestinal hemorrhage occurrence probability after total endoprosthesis of the hip and knee joint were studied. Of 526 patients in 4 (0.7%) after the total joint endoprosthesis operation the gastroduodenal ulcer had occurred, demanding the urgent treatment measures conduction.

[First experience of bilateral hip joint prosthesis using DePuy ASR system].

Simultaneous bilateral hip joints prosthesis owes advantages over two-staged procedure, including the patients stationary treatment shortage, as well as duration of total operative time, total period of his disablement and financial expenses. Decision about application of such operations must be done individually, comparing the real criteria of risk for patient's life.

[First experience of the hip joint prosthesis using DePuy ASR system].

The system of the hip joint total endoprosthesis DePuy owes undoubted advantages over standard metal-polymer systems and constitutes the optimal one on the modern stage of endoprosthesis development for young patients, it permits to escape the revision prosthesis. Early return of the patients to labour activity and short period of adaptation constitute economical efficacy of the construction applied.

[Structure and function of thyroid hormone receptors].

The new data concerning the structure of nuclear receptor of thyroid hormone and peculiarities of its functioning as a ligand-dependent transcriptional factor are reviewed. Considerable attention is concentrated on the analysis of mechanisms of receptor interactions with specifical DNA regions which mediate iodothyronine influence on the gene expression and factors that participate in regulation of these mechanisms.

[Effect of thyroxine on the activity of some enzymes of energy metabolism in bone marrow myeloid cells and blood neutrophils from piglets].

The influence of thyroxine on the activities of enzymes of energy metabolism (hexokinase, 6-phosphofructokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphate dehydrogenase, NADP-isocitrate dehydrogenase, cytochrome c oxidase) was investigated in bone marrow myeloid cells and blood neutrophils of 3-10-day old neonatal piglets. Data obtained suggest different responsiveness of energy metabolism enzymes to thyroxine action. Repeated hormone injections resulted in the preferential stimulation of enzymes involved in oxidative stages of carbohydrate catabolism in animal myelocaryocytes, while the activities of anaerobic enzymes in these cells were less affected.