Publications by authors named "N Nollen"

Article Synopsis
  • The nicotine metabolite ratio (NMR) serves as a stable marker for assessing how quickly the body processes nicotine and is useful for customizing smoking cessation efforts.
  • Researchers examined the role of genetic variations in the CYP2A6 gene and their link to NMR in a sample of 953 African American smokers.
  • They discovered several genetic variants associated with NMR, leading to an improved genetic risk score (GRS) that not only predicts NMR in African Americans but also enhances its applicability to smokers of European descent.
View Article and Find Full Text PDF

Background: The proposed FDA product standard to prohibit menthol as a characterizing flavor in combustible cigarettes has the potential to significantly reduce tobacco-related health disparities. Whether a menthol e-liquid product standard would improve or hinder public health is unknown. No known research has directly examined the impact of menthol vs.

View Article and Find Full Text PDF

Introduction: Alternative Nicotine Delivery Systems (ANDS) such as e-cigarettes (EC) and oral nicotine pouches (ONP) may facilitate the substitution of smoking for those unwilling to quit. This pilot study assesses the harm-reduction potential of EC and ONP among smokers with low socioeconomic status (SES).

Aims And Methods: Adults who smoked daily in the past 6 months, had a household income < 250% federal poverty level and had no intention of quitting smoking in the next 30 days were randomized 2:2:1 to 8 weeks of 5% nicotine EC; 4 mg ONP or assessment-only control (CC).

View Article and Find Full Text PDF

Varenicline, the most efficacious smoking cessation monotherapy, produces abnormal dreams. Although genetic contributions to varenicline-associated nausea and cessation have been identified, the role of genetics in abnormal dreams is unknown. We conducted a genomewide association study (GWAS) of abnormal dreams in 188 European ancestry smokers treated with varenicline (NCT01314001).

View Article and Find Full Text PDF

Introduction: E-cigarettes and heated tobacco products (HTPs) may serve as potential options for harm reduction for smokers if they possess reward profiles similar to cigarettes. Little is known about the abuse liability of HTPs and e-cigarettes versus cigarettes in racial/ethnic minority smokers.

Aims And Methods: Twenty-two nicotine-deprived people who smoke (black [n = 12] and white [n = 10]) completed three visits that included a standardized 10-puff bout followed by a 50-minute ad libitum use assessment with their usual brand cigarette (UBC), an e-cigarette, and HTP.

View Article and Find Full Text PDF