Publications by authors named "N Noguchi"
Background: Paliperidone is a second-generation antipsychotic and the main active metabolite of risperidone, formulated to provide consistent therapeutic effects through an extended-release system, designed to provide consistent therapeutic effects through an extended-release formulation. While commonly used in clinical practice, switching from risperidone to paliperidone, particularly during valproate therapy, can pose challenges due to potential pharmacokinetic interactions that may increase the risk of extrapyramidal symptoms (EPS). Despite clinical observations suggesting these interactions, case reports documenting such adverse effects are scarce.
View Article and Find Full Text PDFEnzymatically formed side-chain oxysterols function as signaling molecules regulating cholesterol homeostasis and act as intermediates in the biosynthesis of bile acids. In addition to these physiological functions, an imbalance in oxysterol homeostasis has been implicated in pathophysiology. Cholesterol 25-hydroxylase (CH25H) and its product 25-hydroxycholesterol (25-OHC), also formed by autoxidation, are associated with amyotrophic lateral sclerosis.
View Article and Find Full Text PDFA 62-year-old man was referred to our hospital presenting with a sore throat, dyspnea, and cervical swelling. Initial precontrast CT scans revealed a cervical and mediastinal hematoma, along with a hemothorax. Further dynamic contrast-enhanced CT scans indicated contrast media extravasation dorsal to the right thyroid gland lobe, suggesting a rupture of the right inferior thyroid artery or a parathyroid adenoma.
View Article and Find Full Text PDFArticle Synopsis
- Parkinson's disease (PD) is a common neurodegenerative disorder that lacks effective treatments and early diagnosis methods, highlighting the need for new diagnostic and treatment strategies.
- The study investigates post-translational modifications of the DJ-1 protein in red blood cells, specifically focusing on the oxidized form of DJ-1 (oxDJ-1) and its altered levels in PD patients compared to healthy individuals.
- Researchers identified a potential new biomarker for early PD diagnosis by analyzing DJ-1 ratios and observing changes in its acidic form that correlate with disease progression and treatment status.
Objectives: Physical inactivity and sedentary time can worsen mental health; however, their relationship remains elusive, and related evidence among workers with overseas assignments is limited. Therefore, this study aimed to investigate the relationship between changes in physical activity and sedentary time and explored the subsequent risk of psychological distress among Japan Self-Defense Forces personnel.
Methods: This prospective study enrolled male Japan Self-Defense Forces personnel dispatched to the Republic of Djibouti from May 2018 to June 2019.